This guy thinks so. He presents a thoughtful study based on three types of law. Go there if you wish, and think it over for yourself.
Here's an excerpt:
international law of secession is in the process of emerging at this
very time. The U.N. Universal Declaration of Human Rights indicates that
all people have the right to a country. A corollary of this is that no
people should long be kept in nationless status, e.g., the Palestinians.
A further corollary of this is that no people should long be kept in
any subjugated status, such as by being citizens or subjects of a
country from which they are alienated."
argument for secession under emerging international law might be
strongest for Alaska. Geographically, the place is disjoint from the
other states of the Union, making it an identifiable place. Furthermore,
under their state constitution's explicit right of privacy, possession
of small amounts of marijuana is a right; yet, the so-called federal
government imposes the costs of its war on drugs onto the citizens of
people of Alaska have been long frustrated in developing their natural
resources because of the opposition by majorities in the "lower 48."
Indeed, as a separate nation, Alaska might be the freest place in the
world, with zero taxes because of its wealth in natural resources,
well-established civil liberties, and a socially tolerant,
live-and-let-live attitude among its people."
I don't know if this is inevitable, or desirable, and you must draw your own conclusions.